fa P14: Therapeutic Potential of Induced Pluripotent Stem Cells for Spinal Cord Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p style="text-align: center;">لطفاً به چکیده انگلیسی مراجعه شود.</p> <p style="text-align: justify;">Spinal cord injury (SCI) is a destructive&nbsp;event that often lead to permanent neurologic deficit. Current clinical treatments are aimed at preventing secondary damage, promoting regeneration, and replacing destroyed spinal cord tissue, although effective treatments for SCI remain limited. Cell therapies for treating SCI are promising therapy for&nbsp;replacing&nbsp;dead cells, neuroprotection and axon regeneration. A number of different pluripotent, multipotent, and differentiating stem cells have been investigated so far for the treatment of SCI. Some of these cells have entered or will soon be entering clinical trials. Basic and pre-clinical experimental studies have highlighted the positive effects of Induced pluripotent stem cells (iPSCs) treatment after spinal cord and peripheral nerve injury. iPSCs are a type of pluripotent stem cell that directly can be generated from adult cells and their therapeutic effects are believed to be due to their potential to differentiate into neural precursor cells, neurons, oligodendrocytes, astrocytes &nbsp;and neural crest cells that can act by replacing lost cells or providing environmental support. iPSCs can provide a cell source that has characteristics of embryonic stem cells. However, human iPSCs solve the&nbsp;ethical dilemma posed by human embryonic stem cells research.&nbsp;In addition, they can be sourced from autologous sources, which may decrease the risk of immune rejection.</p> Spinal Cord Injury, Clinical Translation, Neuroprotection, Cell Therapy, Neuroregeneration 41 41 http://shefayekhatam.ir/browse.php?a_code=A-10-24-647&slc_lang=fa&sid=1 Sara Abdolahi Sara Abdolahi Abdolahisara65@gmail.com 10031947532846007759 10031947532846007759 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Biotechnology, School of Veterinary Science, Shiraz University, Shiraz, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Biotechnology, School of Veterinary Science, Shiraz University, Shiraz, Iran Maryam Borhani-Haghighi Maryam Borhani-Haghighi 10031947532846007760 10031947532846007760 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran Hadi Aligholi Hadi Aligholi 10031947532846007761 10031947532846007761 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran