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:: Volume 5, Issue 1 (Winter - 2017) ::
Shefaye Khatam 2017, 5(1): 73-86 Back to browse issues page
Oxidative Stress and its Different Roles in Neurodegenerative Diseases
Sadegh Rajabi, Shokoofeh Noori, Fatemeh Zal, Ali Jahanbazi Jahan-Abad *
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , a.jahanbazi65@yahoo.com
Abstract:   (3651 Views)

Introduction: The incidence and prevalence of neurodegenerative diseases increase with life expectancy. Brain, for physiological and biochemical reasons, has a high sensitivity to oxidative stress. Therefore, maintaining the redox homeostasis is essential for brain cells. In addition, brain antioxidant levels are limited compared to other tissues. In this article, different mechanisms involved in the production of endogenous and exogenous reactive oxygen species and the role of oxidative stress in neurodegenerative diseases were discussed. Redox imbalance occurs when antioxidant capacity doesnchr('39')t overcome free radicals, which can lead to tissue damage, cell death or disease onset. This article also reviews various molecular and signaling mechanisms involved in oxidative stress management in neurodegenerative diseases. Conclusion: Although the induction and role of oxidative stress in neurodegenerative disease have been approved, its role in pathogenesis of some of the neurodegenerative diseases needs to be further investigated. It is possible that with antioxidant therapy, we could modulate oxidative status and prevent or treat these diseases.

Keywords: Neurodegenerative Diseases, Reactive Oxygen Species, Antioxidants
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neurology

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Rajabi S, Noori S, Zal F, Jahanbazi Jahan-Abad A. Oxidative Stress and its Different Roles in Neurodegenerative Diseases. Shefaye Khatam. 2017; 5 (1) :73-86
URL: http://shefayekhatam.ir/article-1-1142-en.html

Volume 5, Issue 1 (Winter - 2017) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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