Experimental Models of Rheumatoid Arthritis: Acute and Chronic Pain
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Ali-Mohammad Khanizadeh , Fariba Karimzadeh * |
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran , Fariba_karimzade@yahoo.com |
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Abstract: (5108 Views) |
Introduction: Rheumatoid arthritis is the most common chronic inflammatory autoimmune disease with unknown etiology and pathophysiology with various symptoms, such as pain, hyperalgesia, and edema. Changes in the level of cytokines, such as TNF-α, IL-6 and IL-1β, are among mechanisms which have been suggested to cause chronic inflammation and have a key role in the design of experimental models of rheumatoid arthritis. The main experimental models of rheumatoid arthritis are Carageen, CFA, collagen-induced arthritis and Zymosan models. In these models, occurrence of thermal hyperalgesia, mechanical allodynia, and pain-induced motor impairment have been reported. These models assess the effectiveness of medications and the mechanisms of pain relief in rheumatoid arthritis. Conclusion: The use of a valid model of rheumatoid arthritis could help to investigate the pathophysiological mechanisms of pain and improve our studies on appropriate treatments for pain. |
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Keywords: Arthritis, Rheumatoid, Pain, Disease |
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Full-Text [PDF 777 kb]
(3307 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Pain
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