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:: Volume 5, Issue 1 (Winter - 2017) ::
Shefaye Khatam 2017, 5(1): 98-109 Back to browse issues page
Experimental Models of Rheumatoid Arthritis: Acute and Chronic Pain
Ali-Mohammad Khanizadeh, Fariba Karimzadeh *
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran , Fariba_karimzade@yahoo.com
Abstract:   (2697 Views)

Introduction: Rheumatoid arthritis is the most common chronic inflammatory autoimmune disease with unknown etiology and pathophysiology with various symptoms, such as pain, hyperalgesia, and edema. Changes in the level of cytokines, such as TNF-α, IL-6 and IL-1β, are among mechanisms which have been suggested to cause chronic inflammation and have a key role in the design of experimental models of rheumatoid arthritis. The main experimental models of rheumatoid arthritis are Carageen, CFA, collagen-induced arthritis and Zymosan models. In these models, occurrence of thermal hyperalgesia, mechanical allodynia, and pain-induced motor impairment have been reported. These models assess the effectiveness of medications and the mechanisms of pain relief in rheumatoid arthritis. Conclusion: The use of a valid model of rheumatoid arthritis could help to investigate the pathophysiological mechanisms of pain and improve our studies on appropriate treatments for pain.

Keywords: Arthritis, Rheumatoid, Pain, Disease
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Pain

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Khanizadeh A, Karimzadeh F. Experimental Models of Rheumatoid Arthritis: Acute and Chronic Pain. Shefaye Khatam. 2017; 5 (1) :98-109
URL: http://shefayekhatam.ir/article-1-1143-en.html

Volume 5, Issue 1 (Winter - 2017) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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