Introduction: According to the importance of psychological factors in psychosomatic disorders and multiple sclerosis (MS) as well as its importance in early maladaptive schemas in psychological disorders, the present study was aimed to evaluate early maladaptive schemas in patients with psychosomatic disorders and MS and compared that with healthy subjects. Materials and Methods: Research method was ex post facto. This study evaluated 100 patients (50 with MS and 50 with psychosomatic disorder) and compared them to 50 healthy people that completed Young Schema Questionnaire (short form). The study was causal-comparative. Results: The results showed that the average score of vulnerability to harm or illness subscale in people with psychosomatic disorder was higher than healthy people and the average score of emotional deprivation, dependence/incompetence, and failure subscale in patients with MS was higher than healthy group. Conclusion: Early maladaptive schemas should be considered as an important element when comparing patients with psychosomatic disorders and MS with healthy people.