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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 1-1 Back to browse issues page
O 1: The Effects of Vitamin D Supplementation on the T cell Compartment in Multiple Sclerosis
Mohammad Rahneshin *
Student Research Committee, Medicine Faculty, Mashhad University of Medical Science, Mashhad, Iran , RahneshinM941@mums.ac.ir
Abstract:   (1934 Views)

Multiple sclerosis (MS) is a complex neurological disease and its prevalence is about 2 million in the world. Neuroinflammation plays a key role in MS. Vitamins are essential nutrients that have effective role on immune system including activation of lymphocyte and differentiation of T-helper cell. Vitamin D is a micronutrient that is effective on immune function. Deficiently of Vitamin D is a risk factor for progression of MS and studies indicated that 90% of patients with MS have low level of vitamin D. studies showed that there is a relationship between regulatory T cell (Treg) function and Vitamin D status. T lymphocyte and macrophage population have vitamin D receptors especially immature immune cells of the thymus and mature CD8+ lymphocyte. Tregs can be stimulated by Vitamin D supplementation and increased the frequency of Tregs. Also transforming growth factor (TGFβ-1) interleukin 4 (IL-4) can be stimulated by vitamin D that can suppress inflammatory T cell activity. Generally function of vitamin D related to differentiation and activation status of CD4+ T cells. Therefore, attention on other vitamins can be used as an alternative treatment for immune system dysfunction. In this review the effect of vitamin D supplementation and vitamin A on T cell in multiple sclerosis were focused. Previous studies indicate that proportion IL10+ CD4+ were increased and the ratio between IFN- and IL4+ CD4+ T cell decreased by vitamin D. It has been indicated that high dose vitamin D supplementation did not effect on lymphocyte with a regulatory phonotype and the proportion of CD4+ Treg remained unaffected. According to studies, we suggested that other vitamins especially vitamin A can be effective on T cell. T cells that are instigated by Myelin Oligodendrocyte Glycoprotein (MOG) can be reduced by vitamin A.

Keywords: Multiple sclerosis, Vitamin D, Regulatory T cell
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Rahneshin M. O 1: The Effects of Vitamin D Supplementation on the T cell Compartment in Multiple Sclerosis. Shefaye Khatam. 2017; 5 (S2) :1-1
URL: http://shefayekhatam.ir/article-1-1154-en.html

Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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