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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 57-57 Back to browse issues page
P 26: The Protective Effect of Nano-Hesperetin on Memory Disorder Induced by Streptozotocinin Male Rat in Alzheimer Models
Elham Kheradmand *, Akbar Hajizadeh, Mahbobeh Zare, Sedigheh Khanjani Jelodar
Department of biology, Faculty of basic sciences, University of Mazandaran, Babolsar, Iran , elhamkheradmand25@gmail.com
Abstract:   (1673 Views)

Introduction: Intracerebroventricular (i.c.v.) injection of streptozotocin (STZ) to rodents has been reported as an appropriate model for sporadic dementia of Alzheimerchr('39')s type (SDAT), characterized by a progressive impairment of memory. However, very little or nothing is known about non-cognitive behavioral effects in the STZ model. This study was carried out in order to show the protective effects of nano-hesperetin on memory disorder in the brains of Alzheimer’s animal models. Materials and Methods:  49 male rats were divided into 6 groups: control, sham, disease group (rats were injected with STZ), 2 treatment groups receiving 10 and 20 mg/kg/day of Nano-hesperetin. Then 3 µgr/rat of (STZ) was injected to the cerebroventricular of rats of all groups except the control and sham groups. The control and sham and toxin groups received distilled water orally. The two treatment groups were gavaged by, respectively10, 20 mg/Kg of nano-hesperetin 30 days. Then, three successive weeks, recognition memory was examined by shutl box test. Results: The results showed that injection of STZ increases memory disorders (p≤0.001) and treatment of Nano-hesperetin effectively decrease memory disorders (p<0.001) and increases duration that spends in light area of Shuttle box (p<0.01) compared with disease group. Conclusion: the treatment with Nano-hesperetin cause the protect cholinergic neurons against memory disorder in the Alzheimer rat model.

Keywords: Alzheimer’s disease, STZ, Nano-hesperetin, Behavioral test of learning
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Kheradmand E, Hajizadeh A, Zare M, Khanjani Jelodar S. P 26: The Protective Effect of Nano-Hesperetin on Memory Disorder Induced by Streptozotocinin Male Rat in Alzheimer Models. Shefaye Khatam. 2017; 5 (S2) :57-57
URL: http://shefayekhatam.ir/article-1-1211-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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