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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 73-73 Back to browse issues page
P 42: Effect of Hesperetin During Pregnancy and Lactation on Locomotor Activity and Anxiety-Like Behaviors in Animal Model of Autism
Rashin Khalaj *, Akbar Hajizadeh Moghaddam, Mahbobeh Zare, Sedigheh Khanjani Jelodar
Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran , r.khalaj70@gmail.com
Abstract:   (1858 Views)

Introduction: Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders that are defined with a wide range of behavioral impairments including social and communication deficits. Apart from these core symptoms, a significant number of ASD individuals display higher levels of anxiety. The present study is designed to understand the antioxidant efficacy of hesperetin (HET) on locomotor activity and anxiety-like behaviors in an animal model of ASD. Materials and Methods: In the experimental research, pregnant rats were divided into four groups including: control, disease group (injected 500 mg/kg valproic acid at gestational day 13) and treatment groups (received 10 and 20 mg/kg/day hesperetin for7 weeks during pregnancy and lactation). Locomotor activity and anxiety-like behavioral in offspring were measured in the open-field test. Results: The results showed that injection of valproic acid increases locomotor activity and anxiety-like behaviors (p≤0.001) and treatment of hesperetin effectively decrease locomotor activity (p<0.001) and increases duration that spends in middle area of Open field (p<0.01) compared with disease group. Conclusion: The results showed that oral administration of hesperetin improves locomotor disorder and anxiety-like behaviors in valproic acid model of autism-like.

Keywords: Locomotor Activity, Anxiety, Autism, Valproic acid
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Khalaj R, Hajizadeh Moghaddam A, Zare M, Khanjani Jelodar S. P 42: Effect of Hesperetin During Pregnancy and Lactation on Locomotor Activity and Anxiety-Like Behaviors in Animal Model of Autism. Shefaye Khatam. 2017; 5 (S2) :73-73
URL: http://shefayekhatam.ir/article-1-1227-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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