[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Registration::
Site Facilities::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 

..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Volume 5 - The Spring Supplement of Shefaye Khatam 2 - ::
Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 73-73 Back to browse issues page
P 42: Effect of Hesperetin During Pregnancy and Lactation on Locomotor Activity and Anxiety-Like Behaviors in Animal Model of Autism
Rashin Khalaj * , Akbar Hajizadeh Moghaddam , Mahbobeh Zare , Sedigheh Khanjani Jelodar
Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran , r.khalaj70@gmail.com
Abstract:   (3545 Views)

Introduction: Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders that are defined with a wide range of behavioral impairments including social and communication deficits. Apart from these core symptoms, a significant number of ASD individuals display higher levels of anxiety. The present study is designed to understand the antioxidant efficacy of hesperetin (HET) on locomotor activity and anxiety-like behaviors in an animal model of ASD. Materials and Methods: In the experimental research, pregnant rats were divided into four groups including: control, disease group (injected 500 mg/kg valproic acid at gestational day 13) and treatment groups (received 10 and 20 mg/kg/day hesperetin for7 weeks during pregnancy and lactation). Locomotor activity and anxiety-like behavioral in offspring were measured in the open-field test. Results: The results showed that injection of valproic acid increases locomotor activity and anxiety-like behaviors (p≤0.001) and treatment of hesperetin effectively decrease locomotor activity (p<0.001) and increases duration that spends in middle area of Open field (p<0.01) compared with disease group. Conclusion: The results showed that oral administration of hesperetin improves locomotor disorder and anxiety-like behaviors in valproic acid model of autism-like.

Keywords: Locomotor Activity, Anxiety, Autism, Valproic acid
Full-Text [PDF 220 kb]   (1081 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khalaj R, Hajizadeh Moghaddam A, Zare M, Khanjani Jelodar S. P 42: Effect of Hesperetin During Pregnancy and Lactation on Locomotor Activity and Anxiety-Like Behaviors in Animal Model of Autism. Shefaye Khatam 2017; 5 (S2) :73-73
URL: http://shefayekhatam.ir/article-1-1227-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.07 seconds with 45 queries by YEKTAWEB 4645