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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 98-98 Back to browse issues page
P 67: The Role of Neuroinflammation in Dysfunction of Adult Hippocampal Neurogenesis
Farideh Baghishani *, Sajad Sahab Negah, Neda Fazaeli javan, Ehsan Baghishani
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , baghishanif2@mums.ac.ir
Abstract:   (1397 Views)

Neuroinflammation as a protective mechanism for repairing tissue damage in the central nervous system (CNS), has been classified into two types: acute and chronic. It is characterized by the activation of microglia and astrocytes and the increase levels of different chemokines and cytokines. Neuroinflammation can be harmful, and it is a common pathological feature in neurodegenerative and psychiatric conditions. On the other word, neuroinflammation effects on important processes in the brain such as adult neurogenesis. Neurogenesis is the process by which new neurons are generated during the embryonic development of CNS and in the adult brain, and it has an important role in the repairing adult brain. Therefore, we review the effect of neuroinflammation on neurogenesis. Chronic neuroinflammation can impair to hippocampal neurogenesis in the adult brain. It has been proven that chronic neuroinflammation due to increased microglial activation and increased production of pro‐inflammatory cytokines (e.g. interleukin-1β, interleukin-6, and tumor necrosis factor-α.) has deleterious effects on neurogenesis. It has been also demonstrated that microglial activation by reducing cell proliferation and newborn cell survival leads to hippocampal neurogenesis dysfunction in the adult brain. It can be concluded that neurogenesis as a physiologic phenomenon in hippocampus affected by neuroinflammation. New studies in this field can be helped to treat related neurodegeneration disease. 

Keywords: Neuroinflammation, Central nervous system, Acute, Chronic, Neurogenesis
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Baghishani F, Sahab Negah S, Fazaeli javan N, Baghishani E. P 67: The Role of Neuroinflammation in Dysfunction of Adult Hippocampal Neurogenesis. Shefaye Khatam. 2017; 5 (S2) :98-98
URL: http://shefayekhatam.ir/article-1-1253-en.html

Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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