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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 106-106 Back to browse issues page
P 75: Inflammation in the Pathogenesis of Depression
Mohadese Ghanei Sarcheshmeh *
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , ghaneism931@mums.ac.ir
Abstract:   (1639 Views)

Depression is a mental disorder that results from changes in the central nervous system (CNS) that may result from immunological abnormalities. According to the World Health Organization, major depression will become the leading cause of disability worldwide. Accumulating evidence has indicated the existence of reciprocal communication pathways between nervous, endocrine and immune systems. The immune system affects the CNS through cytokines, which regulate brain activities and emotions. Cytokines affect the activity of the two biological systems that are most associated with the pathophysiology of depression: The hypothalamic-pituitary-adrenal axis and the catecholamine/sympathetic nervous system. Pro-inflammatory cytokines and stress are important in inflammatory and neurogenesis and neuroprotection. Stress induces pro-inflammatory cytokines over secretion, which result in activation the HPA axis and neurotransmitter turnover, thus leading to depression. The use of cytokine inhibitors and anti-inflammatory drug is effective in the treatment of the depression. Although there are known effective treatment for depression, fewer than half of these affected in the world. In this review calculated recent literature related to the effect of inflammation on the pathogenesis depression.

Keywords: Inflammation, Central nervous system, Cytokine, Endocrine, Stress
Full-Text [PDF 205 kb]   (277 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Ghanei Sarcheshmeh M. P 75: Inflammation in the Pathogenesis of Depression. Shefaye Khatam. 2017; 5 (S2) :106-106
URL: http://shefayekhatam.ir/article-1-1261-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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