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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 108-108 Back to browse issues page
P 77: The Role of Interleukin-1 in Neurogenesis and Alzheimer Disease
Amir Mahmoud Ahmadzade, Farzin Naseri, Sajad Sahab Negah *
a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , SahabNegahS@mums.ac.ir
Abstract:   (1374 Views)

One of the most serious neurodegenerative disorders is Alzheimer disease (AD). As the population is aging and due to the fact that AD is more common in aged people, more attention must be paid to this disease. One of the main characteristics of AD is dementia which starts with loss of short term memory, then progresses and causes various brain dysfunctions such as loss of long term memory. Interleukin-1 is a pluripotent cytokine that initiates inflammatory responses in different parts of body such as brain. In a study, it has been shown that IL-1 upregulates the expression of β-amyloid precursor protein (β-APP) that plays an important role in AD pathogenesis. A previous study represents that IL-1 induces production of substrates that are essential for making neuropathological changes characteristic of AD. Another research says that IL-1 affects the pathogenesis of AD through increasing the translation of APP mRNA. Interestingly an article claims that IL-1β-driven neuroinflammation has a possible adaptive role in AD. It has been broadly demonstrated that neuroinflammation influences adult neurogenesis. The duration of inflammation leads to inhibition or promotion of neurogenesis. Hence, modulating neuroinflammatory cytokines such as IL-1 may help in the prevention of AD or halting its progression.

Keywords: Neuroinflammation, Alzheimer disease, Interleukin-1
Full-Text [PDF 208 kb]   (333 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Ahmadzade A M, Naseri F, Sahab Negah S. P 77: The Role of Interleukin-1 in Neurogenesis and Alzheimer Disease. Shefaye Khatam. 2017; 5 (S2) :108-108
URL: http://shefayekhatam.ir/article-1-1263-en.html

Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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