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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 119-119 Back to browse issues page
P 88: Matrix Metalloproteinases in Neuroinflammation
Fatemeh Forouzanfar, Mohammad Bagher Khorrami, Sajad Sahab Negah *
Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , sahabsajad@yahoo.com
Abstract:   (1399 Views)

Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the components of the basal lamina and contribute to the neuroinflammatory response in several neurological diseases. In response to cellular stress the brain cells express both constitutive and inducible MMPs. The MMPs belong to a larger class of metalloproteinases (MPs), which includes proteins containing a disintegrin and metalloproteinase domain (ADAM). MPs have complex roles at the cell surface and in the extracellular matrix. At the cell surface they are essential for cell survival and death. MMPs are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs) that regulate the activity of them. MMP inhibitors have been developed for the treatment of several neurological disorders such as Alzheimer’s disease, Multiple sclerosis, spinal cord injury, and traumatic brain injury. Since MMPs have both beneficial and detrimental roles; understanding their expression in numerous CNS insults and the use of MMP inhibitors is a good topic for scientists that will help in the treatment of the neurological disease. 

Keywords: Matrix metalloproteinases, Neuroinflammation, Extracellular matrix
Full-Text [PDF 212 kb]   (314 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Forouzanfar F, Khorrami M B, Sahab Negah S. P 88: Matrix Metalloproteinases in Neuroinflammation. Shefaye Khatam. 2017; 5 (S2) :119-119
URL: http://shefayekhatam.ir/article-1-1274-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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