[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 5 - The Spring Supplement of Shefaye Khatam 2 - ::
Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 122-122 Back to browse issues page
P 91: The Evaluation of Serum Level of 25-Hydroxy Vitamin D in Patients under Sodium Valproate Medication
Sepideh Mansoori Majoofardi *, Zahra Sheidae Mehne
a. Student Research Committee‚ Facuilty of Medicine‚ Islamic Azad University‚ Mashhad branch‚ Mashhad, Iran b. Gastric Cancer Research Group‚ Mashhad University of Medical Science‚ Mashhad‚ Iran , sepideh.mansoori91@gmail.com
Abstract:   (1466 Views)

Epilepsy is one of the common neurologic disorders in children. Drug side-effects are one of the important problems in treating patients with epilepsy. Using the antiepileptic medication may cause different side effects such as disorder in bone and vitamin D metabolism. Sodium valproate is one of the antiepileptic medications used widely. Some of its side effects include digestive disorder, increasing of level hepatic enzymes, fatal hepatitis, decreasing level of vitamin D, and etc. The evaluation of serum level of 25-hydroxy vitamin D in patients who are treated with sodium valproate for a long time and presenting suggestions to decrease its side effects. This review study is performed by searching valid internal and external scientific databases (Science Direct, PubMed ‚Google scholar, SID and etc.) by related keywords. Recent researches have shown that antiepileptic medications including sodium valproate commonly cause a decrease in vitamin D level. Also, decrease in the measurement of bone marrow density (BMD) in patients treating with sodium valproate for a long time has been proved. So, periodic measurement of the level of 25-hydroxy vitamin D in children with epilepsy who were treated with sodium valproate is suggested. Also, consuming prophylactic vitamin D is necessary for these patients. Considering the mentioned side effects, it is suggested that this drug should not be consumed by children under 2 year old and pregnant women.

Keywords: Epilepsy, Antiepileptic medication, 25-hydroxy vitamin D‚ Sodium valproate
Full-Text [PDF 208 kb]   (313 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mansoori Majoofardi S, Sheidae Mehne Z. P 91: The Evaluation of Serum Level of 25-Hydroxy Vitamin D in Patients under Sodium Valproate Medication. Shefaye Khatam. 2017; 5 (S2) :122-122
URL: http://shefayekhatam.ir/article-1-1278-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4212