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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 123-123 Back to browse issues page
P 92: A Critical Balance between Repair and Demolish of Proinflammatory Factors to Improve Effects of Neuroinflammation
Mahtab Irani *, Fatemeh Yardehnavi, Zohreh J Memari
a. Islamic Azad University, Mashhad Branch, Mashhad, Iran b. Member of Mashhad Neuroscience Research Group of Islamic Azad University, Mashhad Branch, Mashhad, Iran , irani.m1372@gmail.com
Abstract:   (1630 Views)

One of the most important problems in neuroscience researches is the understanding what is the communication between the immune system and central nervous system. Proinflammatory factors play an important role in this communication. The dysregulation of proinflammatory factors such as cytokines and chemokines is a central feature in the development of neuroinflammation.one of the important  cytokines is tumor necrosis factor superfamily molecules that role of this cytokine is in the activation, proliferation, differentiation ,and migration of immune cells into the central nervous system. Another important cytokines especially in the onset of inflammatory process is interleukin-1 because of overexpression of this factor which affects with produces many reactions that cause dysfunction and neuronal death. Neuroinflammation is inflammation of the nervous tissue and it is immune response to variety of cues such as infection, toxic metabolites, traumatic brain injury, or autoimmunity. The central nervous system is an immunologically privileged site because the role of blood brain barrier, it has special structure that is composed of astrocytes and endothelial cells. This review will focus on how proinflammatory factors affect neuroinflammation process.

Keywords: Neuroinflammation, Proinflammatory, Cytokine
Full-Text [PDF 213 kb]   (396 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Irani M, Yardehnavi F, J Memari Z. P 92: A Critical Balance between Repair and Demolish of Proinflammatory Factors to Improve Effects of Neuroinflammation. Shefaye Khatam. 2017; 5 (S2) :123-123
URL: http://shefayekhatam.ir/article-1-1279-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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