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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 125-125 Back to browse issues page
P 94: The Systemic Inflammation after Spinal Cord Injury
Sara Abdolahi *, Zahra Aeini, Robabeh Jafari, Zeinab Najmi, Maryam Jafari, Ali Jahanbazi Jahan Abad
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran , abdolahisara65@gmail.com
Abstract:   (1361 Views)

Spinal cord injury (SCI) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms. Neuroinflammation is an important secondary injury process in SCI. The local inflammatory microenvironment within the injured spinal cord is a collection of degenerating neurons, damaged endothelial cells, degraded myelin sheath, and this microenvironment produces various kinds of pro-inflammatory mediators. There are many other factors such as dysregulation of the neuroendocrine system and changed neuroimmune regulation that important determinant of the onset and progression of post-SCI systemic inflammation. Epidemiological analyses have unfolded a functional link between systemic inflammation and pathogeneses of post-injury complications. On the other hand cognitive impairment is associated with extensive cerebral inflammation after SCI. SCI triggers systemic inflammatory responses marked by increased circulation of immune cells and pro-inflammatory mediators, which result in the permeation of inflammatory cells into secondary organs and durability of an inflammatory microenvironment that chip in organ dysfunction. 

Keywords: Spinal cord injury, Inflammation, Neuroendocrine
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Abdolahi S, Aeini Z, Jafari R, Najmi Z, Jafari M, Jahanbazi Jahan Abad A. P 94: The Systemic Inflammation after Spinal Cord Injury. Shefaye Khatam. 2017; 5 (S2) :125-125
URL: http://shefayekhatam.ir/article-1-1281-en.html

Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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