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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 128-128 Back to browse issues page
P 97: Neurodegeneration Induced by Tau protein
Nikoo Mohmmadpour *
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , nikoompr@gmail.com
Abstract:   (1321 Views)

Tau is one of several types of microtubule-associated proteins (MAPs), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. Via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses, aberrant calcium homeostasis, imbalanced neurotransmitter release, and ultimately with neuronal death which aggregated in several neurodegenerative diseases, collectively known as tauopathies including Alzheimerchr('39')s disease (AD), several frontotemporal dementias and etc. Neurodegeneration is the progressive loss of structure or function of neurons and neuroinflammation is a critical marker of these diseases, in addition to protein aggregates. This review looks at various factors that are considered for explaining mechanism of tau proteins that can induce neurodegeneration. These different factors include two conformations of phosphorylated tau (cis p-tau and trans p-tau), the level of PH-tau expression, hyper phosphorylation of certain amino acids in tau proteins, mutations in the tau gene (MAPT), tau neurotoxicity and etc. Taking together, these results help to consider tau as a remarkable factor for treatment of tauopathies. The effect of tau disturbances on neurodegenerative disorders has been looked in many different ways. According to these results, tau can be studied as a potential target for drug development especially in the field of AD and other treatment options including immunotherapy.

Keywords: Tau proteins, Neurodegenerative diseases, Neuroinflammation
Full-Text [PDF 201 kb]   (342 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Mohmmadpour N. P 97: Neurodegeneration Induced by Tau protein. Shefaye Khatam. 2017; 5 (S2) :128-128
URL: http://shefayekhatam.ir/article-1-1284-en.html

Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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