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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 139-139 Back to browse issues page
P 108: Evaluation of Calcineurin Role in Neuroinflmmation: Possible Targets for Early Detection and Treatment
Mokhtar Ahmadi, Hossein Feizi *, Fatemeh Shahbeigi
Islamic Azad University, Mashhad Branch, Mashhad, Iran , h.feyzi28974@gmail.com
Abstract:   (1491 Views)

Calcineurin (CaN) is a Ca2+/calmodulin (Ca2+/CaM)-dependent serine/threonine protein phosphatase expressed in most mammalian tissues but found at higher concentration in brain. In the last decade there have been a steadily increasing number of studies identifying neuronal CaN as a primary suspect in neuronal vulnerability, synapse loss, dendritic atrophy, synaptic dysfunction and neuroinflammation Subsequently despite the apparently selective association of CaN with neurons and neuronal signaling cascades, many studies found that CaN, can also appear in primary glial cells and glial cells of healthy brain tissue and astrocytes, prominently following inflammatory insult The clear connection between glial cells / astrocytes and neuroinflammatory signaling, in addition to the well-known the role of CaN in cytokine production in peripheral immune cells, suggested a potent association between glial CaN and the neuroinflammation inherent to most acute and chronic neuroinflammatory autoimmune diseases. In this review we aim to evaluate the Calcineurin role in neuroinflammation as an early event. Recent studies highly confirmed CaN as a major modulator of immune/inflammatory processes in glial cells and astrocytes that higher expression of CaN associated with early stage of neuroinfllammatory autoimmune disease that makes CaN as novel target for early detection and treatment of neuroinflammatory autoimmune diseases.

Keywords: Calcineurin, Neuroinflmmation, Early detection, Treatment
Full-Text [PDF 212 kb]   (383 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Ahmadi M, Feizi H, Shahbeigi F. P 108: Evaluation of Calcineurin Role in Neuroinflmmation: Possible Targets for Early Detection and Treatment. Shefaye Khatam. 2017; 5 (S2) :139-139
URL: http://shefayekhatam.ir/article-1-1295-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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