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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 162-162 Back to browse issues page
P 131: Connection Process Inflammation and Improvement Alzheimer’s Disease
Mahboobeh Paporaki *, Zeinab Sadat Hosseini, Fatemeh Razmi, Fatima Sadat Zojaji
Islamic Azad university, Mashhad Branch, Mashhad, Iran , m.paporaki@gmail.com
Abstract:   (1318 Views)

Platelet aggregation beta amyloid main causes inflammation of neurons in Alzheimer’s disease. In fact, creating this inflammation due to inappropriate actions in blood brain barrier (BBB) and astrocyte and microglia during the last century that studies conducted in this case nothing has been found. The only thing that can be done to prevent and reduce pro-inflammatory factors such as cytokines and beta-amyloid. Non-steroidal drug have little effect on reducing inflammation and may even aggravate the inflammation. The combination of polyphenols can inhibit the accumulation of beta-amyloid and oxidative stress. This combines decrease the production and accumulation caused by cytokines. One of the significant factors in the recovery process of Alzheimer’s disease is TNFSF-10 that have anti-tumoral feature and reduce the accumulation of beta-amyloid clumps. According to research conducted by intraperitoneal injection of TNFSF-10factor has been effective in improving Alzheimer’s disease. Reducing the activity of microglia and astrocytes cause of reduced accumulation of beta-amyloid also reduces inflammatory biomarkers from astrocytes and microglia.

Keywords: Alzheimer’s diseases, TNFSF-10, Beta-amyloid, Neuroinflammation
Full-Text [PDF 201 kb]   (282 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Paporaki M, Hosseini Z S, Razmi F, Zojaji F S. P 131: Connection Process Inflammation and Improvement Alzheimer’s Disease. Shefaye Khatam. 2017; 5 (S2) :162-162
URL: http://shefayekhatam.ir/article-1-1319-en.html

Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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