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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 180-180 Back to browse issues page
P 149: Effect of Glycoprotein IIb/IIIa Inhibition on Acute Ischemic Stroke Injuries
Neda Kamandi, Niloufar Akhgari, Sajad Sahab Negah *
Department of Neuroscience, Medicine Faculty, Mashhad University of medical sciences, Mashhad, Iran , Sahabsajad@yahoo.com
Abstract:   (1491 Views)

Ischemic stroke accounts for about 87 percent of all cases. It occurs as a result of an obstruction within a vessel of the brain and sudden loss of blood circulation to the corresponding area resulting in the loss of brain function. It is caused by thrombotic or embolic occlusion of an artery and is more common than hemorrhagic stroke. We know that most of the injuries after an acute ischemic stroke are due to thrombosis formation and the following neuroinflammation (thromboinflammation). So by blocking this pathway we can ameliorate the injuries and the infarct size and improve the brain function after an acute stroke. Platelet von willebrand factor (VWF) is a glycoprotein involved in hemostasis. It is released from the platelet alpha granules and binds to glycoprotein IIb/IIIa complex which forms a bridge between the sub endothelial surface and the platelet and promotes thrombosis formation. On the basis of this information, we hypothesize that we can alleviate the injuries of acute ischemic stroke by blocking the glycoprotein IIb/IIIa complex via a specific antagonist antibody and so preventing thrombosis formation. It can be a potential therapeutic approach in the treatment of acute ischemic stroke.

Keywords: Acute ischemic stroke, Neuroinflammation, Thromboinflammation, platelet von willebrand factor, glycoprotein IIb/IIIa
Full-Text [PDF 204 kb]   (415 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Kamandi N, Akhgari N, Sahab Negah S. P 149: Effect of Glycoprotein IIb/IIIa Inhibition on Acute Ischemic Stroke Injuries. Shefaye Khatam. 2017; 5 (S2) :180-180
URL: http://shefayekhatam.ir/article-1-1337-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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