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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 186-186 Back to browse issues page
P 155: The Roles of Microglia in Neurodegenerative Diseases
Fatemeh Alipour, Maryam Borhani-Haghighi *
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , borhanihm@gmail.com
Abstract:   (1386 Views)

Microglia is a type of glial cell located throughout the central nervous system (CNS), which is sensitive to CNS injury and disease. Responsibility of microglia as the resident macrophage cells for injuries suggests that these cells have the potential to act as diagnostic markers of disease beginning or progression. Function of Microglia is strongly synchronized by the microenvironment of brain and spinal cord, many evidences suggest that neurodegeneration and ageing, can affect microglial phenotype and function. Distinctive potassium channels responsible for sensitivity of the cells to even small modifications in extracellular potassium after even small pathological changes in CNS. Microglia cells are very plastic, and undertake a variety of structural transformations based on location and needs. There are different forms and types of microglias in CNS such as Ramified, Non-phagocytic, Phagocytic, Amoeboid, Gitter cells, Perivascular and Juxtavascular. Microglia cells have a significant role in neurodegenerative disorders, for example there are numerous over expressing InterlukinL-1 microglia in the brains of person with Alzheimer’s disease. This over expression of InterlukinL-1 leads to extreme tau phosphorylation that is associated with tangle development in Alzheimerchr('39')s disease. So according to characteristics and behavior of these cells in different neurodegenerative diseases, activated microglia cells can be one of the main cellular target for therapy.


Keywords: Microglia, Central nervous system, Neurodegenerative
Full-Text [PDF 208 kb]   (313 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Alipour F, Borhani-Haghighi M. P 155: The Roles of Microglia in Neurodegenerative Diseases. Shefaye Khatam. 2017; 5 (S2) :186-186
URL: http://shefayekhatam.ir/article-1-1343-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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