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:: Volume 5, Issue 2 (Spring - 2017) ::
Shefaye Khatam 2017, 5(2): 124-129 Back to browse issues page
Effects of Ecstasy on the Nervous System
Amirreza Katebi , Yasmina Katebi , Fereshte Golab *
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran , Fgolab520@gmail.com
Abstract:   (819 Views)

Introduction: Ecstasy is a strong hallucinogenic drug, which is widely used as a street drug. It can improve mood and social relationships in the short term. Studies in humans and animals have shown that ecstasy can cause toxic effects on the nervous system. Although many research has been done on ecstasy but its mechanism of action is still not fully understood. Ecstasy is capable to inhibit serotonin in axon terminals of the brain in rats and mice. It destroyed neurons in the hippocampus, basal ganglia, insula, and parietal cortex. Heat gain, high blood pressure, arrhythmia, liver dysfunction, seizures, memory loss as well as cognitive and mood disorders are among toxic effects of this drug. There are some reports of its toxic effects on the nervous system. Evidence suggest that it can cause resistant psychotic disorders and depression in some consumer. Investigations have shown that the major cause of complications of this drug is reduction of serotonergic system activities. Frequent use of ecstasy (or its addiction) can cause the loss and degradation of the serotonergic neurons. Conclusion: Use of ecstasy is increasing and prevention of its damage to nervous system should be considered. Administration of neuroprotective substances may prevent these complications.

Keywords: Brain, Serotonin, Depression
Full-Text [PDF 363 kb]   (482 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Cognitive Neuroscience



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Katebi A, Katebi Y, Golab F. Effects of Ecstasy on the Nervous System. Shefaye Khatam. 2017; 5 (2) :124-129
URL: http://shefayekhatam.ir/article-1-1365-en.html


Volume 5, Issue 2 (Spring - 2017) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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