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:: Volume 5, Issue 2 (Spring - 2017) ::
Shefaye Khatam 2017, 5(2): 88-97 Back to browse issues page
Seladin-1: A Possible Neuroprotective Agent in Alzheimer's Disease
Sedigheh Ghasemi , Sara Abdolahi , Hoda Pasand Mojdeh , Maryam Borhani-Haghighi *
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , borhanihm@gmail.com
Abstract:   (854 Views)

Introduction: Alzheimer's disease is a progressive brain dysfunction, which damages and destroys neurons and results in memory loss. Selective Alzheimer's disease indicator-1 (seladin-1) is a gene and protein that is found to be down-regulated in specific areas of the brain affected by Alzheimer's disease. Seladin-1 has neuroprotective properties and inhibits caspase-3 activity, a key mediator of apoptosis. Seladin-1 is a multi-functional protein and independently of its activity as a caspase-3 inhibitor, it acts as a cholesterol biosynthetic enzyme. Cholesterol enhances the formation of lipid rafts inhibits the production of β-amyloid in the membrane of neural cell. Cholesterol homeostasis disorder in neural cells may enhance susceptibility of cells to the toxic agents. Conclusion: Studies have shown that the level of seladin-1 increases during brain development to prevent the loss of neuronal precursor cells. Estrogen and thyroid hormones stimulate the expression of seladin-1. It seems that seladin-1 may act as a mediator of these hormones.

Keywords: Alzheimer Disease, Neuroprotective Agents, Cholesterol
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neurology



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Ghasemi S, Abdolahi S, Pasand Mojdeh H, Borhani-Haghighi M. Seladin-1: A Possible Neuroprotective Agent in Alzheimer's Disease. Shefaye Khatam. 2017; 5 (2) :88-97
URL: http://shefayekhatam.ir/article-1-1368-en.html


Volume 5, Issue 2 (Spring - 2017) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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