[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 5, Issue 3 (Summer - 2017) ::
Shefaye Khatam 2017, 5(3): 11-17 Back to browse issues page
Effect of Sex and Age on Repetitive, Stereotyped, and Exploratory Behaviors in a Rat Model of Valproic Acid-Induced Autism
Samaneh Rafiei, Mohammad Amin Edalatmanesh *, Elahe Rezaei
Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com
Abstract:   (3115 Views)

Introduction: Autism is characterized by behavioral impairments in social interaction, language and communication as well as restricted interests and activities. The present study examined stereotypical repetitive behaviors, anxiety, and locomotor as well as exploratory activities in rat model of valproic acid-induced autism. Materials and Methods: Pregnant Spraque dawley rats were administered by either valproic acid (VPA group, 500 mg/kg, n=10) or saline (control group, n=10) during fetal neural tube development on embryonic day 12.5. All male or female offspring were investigated in this study. Stereotypical and anxiety-exploratory behaviors were assessed using Y-maze and open field tests, respectively. Results: A single intra-peritoneal injection of VPA to pregnant rats produced severe autistic-like symptoms in the offspring. The results showed significant behavioral impairments including enhanced stereotyped repetitive behaviors, increased anxiety, and decreased exploratory activities in male rats at postnatal day 30 and 60 compared to female rats. Conclusion: Our data suggest that early embryonic exposure to VPA in rats provides an appropriate model for autism in male offspring.

Keywords: Autistic Disorder, Valproic Acid, Exploratory Behavior
Full-Text [PDF 713 kb]   (963 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rafiei S, Edalatmanesh M A, Rezaei E. Effect of Sex and Age on Repetitive, Stereotyped, and Exploratory Behaviors in a Rat Model of Valproic Acid-Induced Autism. Shefaye Khatam. 2017; 5 (3) :11-17
URL: http://shefayekhatam.ir/article-1-1387-en.html

Volume 5, Issue 3 (Summer - 2017) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4218