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:: Volume 5, Issue 3 (Summer - 2017) ::
Shefaye Khatam 2017, 5(3): 68-82 Back to browse issues page
Inflammation and the Brain Disorders: A Review
Rahimeh Bargi, Hossein Salmani *, Fereshteh Asgharzadeh Yazdi, Mahmoud Hosseini
Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , SalmaniH921@mums.ac.ir
Abstract:   (20814 Views)

Introduction: Inflammation is a physiological response of immune system against internal and external harmful stimulus. However, inflammation is a double-edged sword and can be harmful if it is not properly controlled. Nowadays inflammation is considered as an important factor in the pathophysiology of neurological diseases. Neuroinflammation can be as a result of direct damage to the brain tissues or induced by systemic inflammation. This process is characterized by microglial activation, stimulates astrocytes, blood - brain barrier breakdown and consequent increase in the permeability, penetration of peripheral immune cells into parenchyma of the central nervous system, excessive production of cytokines, nitric oxide, reactive oxygen species as well as prostaglandins and finally, neuronal damage and death. In this study, neuroinflammation and its role in the pathophysiology of brain diseases, including Alzheimerchr('39')s disease, Parkinsonchr('39')s disease, Huntingtonchr('39')s disease, depression, anxiety, epilepsy, schizophrenia and autism are outlined and discussed. Conclusion: Although inflammation has a prominent role in the pathogenesis of neurological diseases, there are no effective and safe treatments to control deregulated inflammatory processes in the brain. The medications usually used to control inflammation are not fully effective in the brain due to lack of BBB penetration. Since many inflammatory processes in the brain is beneficial, modulation of inflammatory responses will be a more efficient therapeutic approach than suppression of inflammatory processes.

Keywords: Neurodegenerative Diseases, Microglia, Nervous System Diseases, Inflammationmation
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neuroimmunology

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Bargi R, Salmani H, Asgharzadeh Yazdi F, Hosseini M. Inflammation and the Brain Disorders: A Review. Shefaye Khatam. 2017; 5 (3) :68-82
URL: http://shefayekhatam.ir/article-1-1391-en.html

Volume 5, Issue 3 (Summer - 2017) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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