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:: Volume 6, Issue 1 (Winter - 2018) ::
Shefaye Khatam 2018, 6(1): 49-60 Back to browse issues page
The Role of Micro-RNAs in Post-Traumatic Stress Disorder
Ali Shahini , Zabihollah Khaksar , Sajad Sahab Negah *
a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , sahabnegahs@mums.ac.ir
Abstract:   (7080 Views)

Introduction: Post-traumatic stress disorder (PTSD) is a form of anxiety disorders. PTSD typically follows an exposure to severe stress. It is characterized by a particular clinical syndrome, including re-experiencing symptoms and alterations in arousal, avoidance, cognition, and mood conditions. Recent evidences propose that micro-RNAs are crucial epigenetic players in mental disorders. It has been demonstrated that micro-RNAs are promising non-invasive biomarkers for different mental health disorders. It has been reported that the levels of micro-RNAs have been changed in psychotic diseases, including Alzheimer's disease and PTSD. Conclusion: Micro-RNAs seem to play a role in pathophysiology of psychological diseases. In this article, we discussed the new findings suggesting a relationship between micro-RNAs and PTSD as well as the possible roles of micro-RNAs in diagnosis and treatment of this mental disorder.

Keywords: Stress Disorders, Post-Traumatic, Amygdala, Hippocampus, Prefrontal Cortex
Full-Text [PDF 984 kb]   (2655 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Molecular Neurobiology



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Shahini A, Khaksar Z, Sahab Negah S. The Role of Micro-RNAs in Post-Traumatic Stress Disorder. Shefaye Khatam 2018; 6 (1) :49-60
URL: http://shefayekhatam.ir/article-1-1437-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6, Issue 1 (Winter - 2018) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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