Introduction: Anxiety and depression are the main psychological problems during premenopause. The present study was aimed to investigate the effectiveness of behavioral activation treatment in reduction of anxiety and depression during premenopausal state. Materials and Methods: This research was a queasy-experimental with a pre-test and post-test design in experimental and control groups. The statistical population were selected among women in Ahvaz city during premenopausal period. From them, 30 women were selected by voluntary sampling method and randomly assigned to two equal groups. The experimental group was received 8 sessions of 90 minutes training with behavioral activation treatment. The groups completed the questionnaire of anxiety (Beck & et al, 1988) and depression (Beck & Clarck, 1988). Results: The results showed that behavioral activation treatment significantly reduced anxiety and depression during premenopausal state. Conclusion: These study indicates that behavioral activation treatment as an effective method for alleviation of anxiety and depression in premenopausal women.