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:: Volume 6, Issue 1 (Winter - 2018) ::
Shefaye Khatam 2018, 6(1): 41-48 Back to browse issues page
The Effect of Lipopolysaccharide Pretreatment on Trauma-Induced Dark Neurons in the Hippocampus
Mansoureh Eslami * , Leila Alizade , Mohammad Sayyah
Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , eslami342@sbmu.ac.ir
Abstract:   (5873 Views)

Introduction: Traumatic brain injury (TBI) is a serious medical condition that affects annually year more than 2 million people worldwide. This study was aimed to evaluate the effect of lipopolysaccharide (LPS) on the number of dark neurons induced by TBI in the parieto-temporal cortex. Materials and Methods:  LPS (0.1 and 0.5 mg/kg) was injected i.p. to rats 5 days before induction of TBI in the parieto-temporal cortex. Using toluidine blue staining, we evaluated the number of dark neurons in the hippocampus in sham and LPS preconditioned rats 4 and 12 hours after the trauma. Results: The increase in dark neurons was significantly higher after 4 h of trauma compared to 12 h after TBI. LPS preconditioning significantly decreased the mean number of dark neurons in the hippocampus. In LPS preconditioned rats the mean number of dark neurons was also significantly higher 4 hours after trauma compared to 12 h after TBI. Conclusion: These data indicate that hippocampal cellular damage produced during the first hours after induction of TBI. This cellular damage could be prevented by administration of LPS.

Keywords: Neurons, Hippocampus, Rats
Full-Text [PDF 1199 kb]   (1850 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neuropharmacology



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Eslami M, Alizade L, Sayyah M. The Effect of Lipopolysaccharide Pretreatment on Trauma-Induced Dark Neurons in the Hippocampus. Shefaye Khatam 2018; 6 (1) :41-48
URL: http://shefayekhatam.ir/article-1-1441-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6, Issue 1 (Winter - 2018) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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