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:: Volume 6, Issue 1 (Winter - 2018) ::
Shefaye Khatam 2018, 6(1): 34-40 Back to browse issues page
The Neuroprotective Effect of Sodium Butyrate on Short-Term Memory and Serum Level of B-cell lymphoma 2 in a Rat Model of Cerebral Hypoxic-Ischemia
Samira Sahraeian , Mohammad Amin Edalatmanesh *
Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com
Abstract:   (5942 Views)

Introduction: Cerebral ischemic stroke is the third cause of death worldwide and is one of the main causes of long-term disabilities. Histone deacetylase inhibitors have effects on amelioration of brain disorders. The purpose of this study was to investigate the effects of sodium butyrate (SB) as a histone deacetylase inhibitor on short-term working memory and serum level of B-cell lymphoma 2 (Bcl2) protein in a rat cerebral hypoxic ischemia (HI) model. Materials and Methods: The animals were divided into 5 groups; control, HI+Saline, HI+SB 0.1, HI+SB 0.3, and HI+SB 0.6. Ischemia was induced by left carotid artery occlusion and then rats were placed in the hypoxic chamber containing 8% oxygen for 5 minute. SB was injected at doses of 0.1, 0.3 and 0.6 (mg/kg/day) intra-peritonealy for 14 consecutive days in three treatment groups. Short-term working memory in these groups was analyzed by Y-maze test. After performing the test, serum value of Bcl2 protein were measured by ELISA. Results: The percent of behavior alteration was higher in treatment groups than HI+Saline group in a dose dependent manner. In addition, SB administration reduced serum levels of Bcl2 in treatment groups. Conclusion: SB may cause amelioration of short-term memory and reduction of Bcl2 level, as an apoptosis marker, in cerebral hypoxic ischemia.

Keywords: Brain Ischemia, Memory, Short-Term, Rats
Full-Text [PDF 507 kb]   (1662 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neuropharmacology



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Sahraeian S, Edalatmanesh M A. The Neuroprotective Effect of Sodium Butyrate on Short-Term Memory and Serum Level of B-cell lymphoma 2 in a Rat Model of Cerebral Hypoxic-Ischemia. Shefaye Khatam 2018; 6 (1) :34-40
URL: http://shefayekhatam.ir/article-1-1442-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6, Issue 1 (Winter - 2018) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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