Introduction: Studies have shown that borderline personality and alexithymia could affect the course of interpersonal problems. The aim of this study was to evaluate borderline personality characteristics and alexithymia among female college students with interpersonal problems. Materials and Methods: Research population included 150 female students in AL Zahra University who were received above cutoff scores in the inventory of interpersonal problems. The instruments used in this study were the inventory of interpersonal problems, the Toronto Alexithymia Scale (TAS-20), and the Personality Assessment Inventory Borderline Scale (PAI-BOR). Results: The results showed that difficulty identifying feelings and impulsive behaviors were predictors of interpersonal problems. Conclusion: These findings indicate the role of borderline personality and alexithymia in interpersonal problems. These results can be useful in intervention programs in treatments of interpersonal problems.