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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 130-130 Back to browse issues page
P99: The Role of C- Reactive Protein in Obesity and Neuropathic Diseases
Samane Arminfar *, Zeinab Sadat Hosseini
Neuroscience Research center, Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran , miss.samane.arminfar@gmail.com
Abstract:   (922 Views)
Acute phase C-reactive protein (CRP), raised in obesity and inflammation, is a main binding protein for leptin. It is assumed that CRP contributes to leptin confrontation by preventing leptin from crossing the blood-brain barrier (BBB). Here we defined how CRP cooperates with the BBB and whether it deters leptin from attainment CNS targets. CRP was constant in blood, but did not permeate the BBB in trace quantities. Though, it increased paracellular permeability at an upper dose. CRP did not permeate hCMEC/D3 cells nor change zona occludin-1 or cyclooxygenase-2 expression. Investigations showed that a middle dose of CRP had no outcome on leptin transport across the BBB after co-therapy. Therefore, acute interactions among CRP and leptin at the BBB level were insignificant and did not elucidate the leptin resistance seen in obesity. The interactions of CRP and the BBB increased paracellular permeability at a high dose that permits its entry into the CNS and aids to induce reactive gliosis and damage CNS activity.
Keywords: Obesity, C- Reactive Protein, Neuroinflammation Diseases
Full-Text [PDF 282 kb]   (311 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Arminfar S, Hosseini Z S. P99: The Role of C- Reactive Protein in Obesity and Neuropathic Diseases. Shefaye Khatam. 2018; 6 (S1) :130-130
URL: http://shefayekhatam.ir/article-1-1529-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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