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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 134-134 Back to browse issues page
P103: The Association between Antibasal Ganglia Antibodies of Streptococcal Infection and Neurological Conditions
Milad Ashrafizadeh *, Zahra Ahmadi
Department of Basic Science, Faculty of Veterinary Medicine, Tabriz University, Tabriz, Iran , Milad Ashrafizadeh
Abstract:   (1300 Views)
The outbreak of the post-streptococcal neurological disorders related to the antibasal ganglia antibodies is broadening. In addition to the disorders such as chorea and obsessive-compulsive disorder which have been recognized previously, the movement and behavioral abnormalities are the other aspects of post-streptococcal neurological disorders.  Streptococcus is a positive-gram and coccus bacteria which causes disease in human. Antibasal ganglia antibodies (ABGAs) are related to the group A-beta haemolytic streptococcal infections (GABHSs). The neurological conditions such as Tourette syndrome (TS), obsessive-compulsive disorder (OCD), acute disseminated encephalomyelitis (ADEM) are associated to the increased levels of ABGAs that we can use the levels of ABGAs as a marker for recognition the origin of those neurologic conditions. It has been showed that the process of generating neurological conditions by ABGAs is an antibody-mediated process. Furthermore, There are several mechanisms for the function of the AGBAs but the underlying mechanism is that the antigens of streptococcus infections imitate molecularly the basal ganglia so that when the antibodies attack those antigens, in fact the basal ganglia are invaded by those antibodies.
Keywords: Antibody, Neurological, Disorder, Ganglia
Full-Text [PDF 227 kb]   (262 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Ashrafizadeh M, Ahmadi Z. P103: The Association between Antibasal Ganglia Antibodies of Streptococcal Infection and Neurological Conditions. Shefaye Khatam. 2018; 6 (S1) :134-134
URL: http://shefayekhatam.ir/article-1-1542-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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