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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 142-142 Back to browse issues page
P111: Effect of Human Neural Stem Cells on Neural Hyperactivity in Kindeling Rat Models
Zahra Gharaeian Morshed, Zinat Heidarnia, Mohammad Mohammadzadeh, Sajad Sahab Negah *
Department of Neuroscience, Mashhad University of Medical Science, Mashhad, Iran , sahabnegahs@mums.ac.ir
Abstract:   (899 Views)
The excessive electrical activity of neurons is reported in many diseases including: Parkinsonchr('39')s disease, Alzheimerchr('39')s disease, and Epilepsy. Electrical overactivity in hippocampus accelerates the depletion of neural stem cell (NSC) and impairs the neurogenesis in hippocampus. It is believed that neurogenesis in hippocampus improves the cognitive functions. In this experiment, we use kindled model of rats to represent the hyperactivity of neurons, using the repeated weak excitation of brain structures that progressively increases sensitivity to the same stimulation. At the end, we will compare the NSC group, vehicle group (which get the resolvent of NSCs), and control group by considering their immunohistochemistry and western blotting samples of each group. Cognitive function and neurogenesis in the hippocampus will be evaluated. Our data probably show that the NSCs can improve the function of the hyperactivated brain and can reduce the complications and impairments due to the hyperactivated neural diseases by change in ratchr('39')s EEG and field potential record.
Keywords: Human Neural Stem Cell, Neural Hyperactivity, Kindeling
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Gharaeian Morshed Z, Heidarnia Z, Mohammadzadeh M, Sahab Negah S. P111: Effect of Human Neural Stem Cells on Neural Hyperactivity in Kindeling Rat Models. Shefaye Khatam. 2018; 6 (S1) :142-142
URL: http://shefayekhatam.ir/article-1-1559-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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