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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 143-143 Back to browse issues page
P112: Tumour Associated Macrophages and Vasculogenic Mimicry: A New Insight in Glioblastoma Treatment
Mohammd Ali Emrani, Sajad Sahab Negah *
Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , sahabnegahs@mums.ac.ir
Abstract:   (891 Views)
Glioblastoma is one of the most common brain tumors in adults with poor prognosis, aggressiveness, and treatment resistance. Vasculogenic mimicry (VM) consists of generating vascular-like channels by tumor cells, independent of endothelial angiogenesis. Studies showed in glioblastoma, the proportion of VM to all vascular channels is associated with poor prognosis and higher invasiveness levels. Tumor-associated macrophages (TAM) play a homeostatic role in glioblastoma maintenance and growth by producing immunosuppressive microenvironment and pro-angiogenic factors. In comparison with low-grade glioma, the number of macrophages in glioblastoma is higher in correlating with a tumour vascular density. Up-regulation of VM markers and increased interleukin 6-type (IL-6) production were observed in tumor–macrophage coculture. Although itchr('39')s indicated that TAM induces VM formation through IL-6, but more studies is needed to clarify the signaling pathways between TAM and VM formation. It can make new insights in glioblastoma treatment in the future
Keywords: Vasculogenic Mimicry, Glioblastoma, Macrophage
Full-Text [PDF 209 kb]   (217 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Emrani M A, Sahab Negah S. P112: Tumour Associated Macrophages and Vasculogenic Mimicry: A New Insight in Glioblastoma Treatment. Shefaye Khatam. 2018; 6 (S1) :143-143
URL: http://shefayekhatam.ir/article-1-1562-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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