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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 152-152 Back to browse issues page
P121: The Effect of Stress on Neuroinflammation in Multiple Sclerosis
Zahra Behrooznia *, Masoud Kashani Lotf Abadi, Somayyeh Behrooznia, Pouya Ghaderi
Student Research Committee, Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Iran , z.behrooznia@gmail.com
Abstract:   (954 Views)
Multiple sclerosis (MS) is a chronic autoimmune disorder of central nervous system. This demyelinating disease affects more than 2.3 million people world wild. Most of patients are young adult. There are many possible triggering factors including infections, toxin, immunization, trauma, sunlight exposure and hormonal variable in pathogenesis of MS. One of the important trigger is stress. There are some substantial evidence that indicates stress can precipitate or worsen symptoms and sign of inflammation in general and more specifically in multiple sclerosis. This review has focused on elucidating the effect of stress on neuroinflammation in multiple sclerosis. The mechanism of stress in MS is not completely understood. There are some proposed theories such as secretion of Corticotropin Relapsing Hormone (CRH) and neurotinensin (NT). These inflammatory factors activate microglia and mast cells leading to maturation and activation of T17 autoimmune cells. Disruption of Blood Brain Barrier (BBB) cause T17 cells to enter in to the CNS. Finally brain inflammation will be worsened. The pathway of stress neuroinflammation can be considered as a therapeutic target for M.S patients. Some evidences indicate Glatiramer Acetat, stress management therapy, Diazepam, Alprazolam and CRH antagonists can reduce brain inflammation So the mechanism of stress in pathogenesis of M.S can be novel therapeutic target.
Keywords: Stress, Neuroinflammation, Multiple Sclerosis
Full-Text [PDF 237 kb]   (264 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Behrooznia Z, Kashani Lotf Abadi M, Behrooznia S, Ghaderi P. P121: The Effect of Stress on Neuroinflammation in Multiple Sclerosis. Shefaye Khatam. 2018; 6 (S1) :152-152
URL: http://shefayekhatam.ir/article-1-1585-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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