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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 171-171 Back to browse issues page
P140: The Roles of Micro RNA in Multiple Sclerosis Disease
Maryam Zareh Rafie, Abdolreza Esmaeilzadeh *
Cancer Gene Therapy Research Center (CGRC), Zanjan University of Medical Sciences, Zanjan, Iran , a46reza@zums.ac.ir
Abstract:   (1018 Views)
As one of the most common neurological disabilities in young adults, Multiple sclerosis (MS) has characteristics of inflammation, demyelination, neuro-axonal damage, and progressive prolonged disability. The disease is clinically divided into three general categories according to response to treatment: Relapsing-Remitting MS (RRMS), Primary Progressive MS (PPMS) and Secondary Progressive MS (SPMS). So, focus of clinical researches has been concentrated on some molecular based strategies such as microRNAs (miR). They are small non-coding RNAs with post transcriptional gene expression function that are located inside exosomes, and could play a role in prognosis, assessment of response to treatment or even estimation of aptitude for disease in healthy patients. Hence, it is hoped that they can be used for timely diagnosis, type of the disease determination, and the risk of future illness. Although clinical examination, imaging, CSF laboratory assessment and electrophysiology are measured out for MS dilemma, there are currently no definitive tests for MS evaluation. Serum miRNAs have been identified as powerful biomarkers, not only detect MS patients from healthy controls, but accurately also detect RRMS from progressive forms of the disease. Indeed, the dysregulation of exosomal miRNA in MS patients and their different expression in different subtypes of the disease, has led to their diagnostic features. miR- 370-3P, miR-432-5P were clearly distinguished between the two different groups (RMMS and PPMS clinical subdivisions). miRNAs could greatly improve early detection and determination of disease categories, as well as the conversion of RRMS to SPMS.
Keywords: Capplication, MicroRNA, Multiple Sclerosis
Full-Text [PDF 247 kb]   (292 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Zareh Rafie M, Esmaeilzadeh A. P140: The Roles of Micro RNA in Multiple Sclerosis Disease. Shefaye Khatam. 2018; 6 (S1) :171-171
URL: http://shefayekhatam.ir/article-1-1623-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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