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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 174-174 Back to browse issues page
P143: The Neuroprotective Effect of Chloroquine in Animal Model of Traumatic Brain Injury
Raziyeh Shahnazi, Ali Siahposht-Khachaki *
Department of Physiology and Pharmacology, Mazandaran University of Medical Sciences, Ramsar International Branch, Sari, Iran , a.siahposht@mazums.ac.ir
Abstract:   (1003 Views)
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality in young adults and children, and is a leading public health problem worldwide. In TBI, neurological impairment is caused by immediate brain tissue disruption (primary injury) and post‑injury cellular and molecular events (secondary injury) that exacerbate the primary neurological insult. However, the destructive molecular events that follow TBI evolve over several days, and therefore there is a window of opportunity during which therapeutic strategies may improve outcome. The antimalarial drug, chloroquine (CQ), has been reported as an autophagy inhibitor in a variety of disorders, including Alzheimerchr('39')s disease and brain ischemia. To the best of our knowledge, no studies to date have examined the potential for CQ to provide neuroprotection in animal models of traumatic brain injury (TBI). Chloroquine (CQ) has long been used in the treatment and prevention of malaria, and less commonly has been employed in the treatment of autoimmune diseases, due to its immunosuppressive properties. In summary, this study demonstrated that neuronal autophagy was inhibited by post‑injury treatment of CQ in a rat model of TBI. Furthermore, CQ attenuates secondary brain edema and improves cognitive functioning. These findings emphasize that CQ administered immediately following injury, could be neuroprotective against the damaging consequences of TBI, and we anticipate that this study has shed light on the potential use of CQ as a neuroprotective agent in the treatment of cerebral injuries.
Keywords: Chloroquine, TBI, Neuroprotective, Rat
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Shahnazi R, Siahposht-Khachaki A. P143: The Neuroprotective Effect of Chloroquine in Animal Model of Traumatic Brain Injury . Shefaye Khatam. 2018; 6 (S1) :174-174
URL: http://shefayekhatam.ir/article-1-1632-en.html

Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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