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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 69-69 Back to browse issues page
P38: The Immunoregulatory Effect of Cyclic Dinucleotides on Human Immune Cells
Lars Masanneck *, Susann Eichler, Niklas Huntemann, Steffen Pfeuffer, Sven G Meuth
Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany
Abstract:   (894 Views)
In multiple sclerosis (MS) beneficial effects have been assigned to the interferon (IFN)-I subclass IFN-ß, making its administration a first-line disease-modifying treatment in MS. IFN-I responses can be induced by cyclic-dinucleotide (CDN) triggered activation of Stimulator-of-interferon-genes (STING) and have essential immunomodulatory effects. A beneficial effect of STING activation on neuroinflammation has been demonstrated in recent in vivo experiments using animal models. Here, we investigate the impact of the CDN-STING-pathway on the regulation of innate and adaptive immune responses. We first disclosed the expression of Sting via real-time PCR (rt-PCR) in murine immune cells linked to MS pathophysiology. Next, we demonstrated that the high expression in some murine immune cells can also be shown in corresponding human-cell subsets. Flow cytometric and rt-PCR analysis showed that in vitro activation of immune cells by CDN leads to strong IFN responses in human peripheral blood monocytes. Consequently, we scrutinized the resulting cytokine effector profile and depicted activation and apoptosis processes in immune cell subsets. Overall, further investigations are needed to clarify the impact of CDNs on individual cell-subsets of innate-adaptive-interface and resulting interactions. By conducting ongoing studies, we aim to achieve insights into CDN and INF specific effects and potential applications for translational medicine.
Keywords: Multiple Sclerosis, Neuroinflammation, Immune Cells, Interferon
Full-Text [PDF 218 kb]   (245 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Masanneck L, Eichler S, Huntemann N, Pfeuffer S, Meuth S G. P38: The Immunoregulatory Effect of Cyclic Dinucleotides on Human Immune Cells. Shefaye Khatam. 2018; 6 (S1) :69-69
URL: http://shefayekhatam.ir/article-1-1633-en.html

Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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