[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 6 - The Spring Supplement of Shefaye Khatam 1 - ::
Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 73-73 Back to browse issues page
P42: The Effects of Vitamin A on Inflammatory Factors (CCL2, CCL18, CD14) in Multiple Sclerosis
Mohammad Rahneshin *, Sajjad Sahab Negah
Neuroscience Department, Mashhad University of Medical Sciences, Mashhad, Iran , rahneshin.mohammad@gmail.com
Abstract:   (1048 Views)

Multiple Sclerosis (MS) is a complex neurological disease in which neuro inflammation that leads to neurodegeneration _ plays a key role and its prevalence is 2 million in the world. Vitamin A is a fat-soluble vitamin that is multifunctional. One of the important functions is in immune system, both in immunological tolerance and in adaptive immune responses. 264 patients will be enrolled that suffer from MS and divided them into two groups. Group (A) will take interferon beta and Vitamin A and group (B) will take interferon beta and placebo. we will follow them for one year and every six months we will check the inflammatory factors in the serum. In this project, we expect that vitamin A regulate CCL2 (as a chemokine) which means vitamin A will increases amount of CCL2 in serum and then CCL2 will effect on TH cells (stimulate TH2 and TReg) and then IL-10 that is anti-inflammatory cytokine will increase and IL-2 that is pro-inflammatory cytokine will be inhibited by IL-10. We guess if vitamin A increases the amount of CCL2 about 50 pg/ml we can see the expected changes. Based on other researches, we expect that vitamin A regulate the inflammatory factors and then reduce the rate and intensity of relapsing in patients.

Keywords: Multiple Sclerosis, Vitamin A, Helper T Cells
Full-Text [PDF 242 kb]   (249 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rahneshin M, Sahab Negah S. P42: The Effects of Vitamin A on Inflammatory Factors (CCL2, CCL18, CD14) in Multiple Sclerosis. Shefaye Khatam. 2018; 6 (S1) :73-73
URL: http://shefayekhatam.ir/article-1-1640-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.04 seconds with 32 queries by YEKTAWEB 4212