[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 6 - The Spring Supplement of Shefaye Khatam 1 - ::
Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 85-85 Back to browse issues page
P54: The Oxidative Stress Assessment of Echium Amoenum on Mice Brain
Afsaneh Mohajer, Atefeh Araghi, Parisa Sadighara *
Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran , Parisasss@yahoo.com
Abstract:   (1326 Views)

Echium Amoenum (Boraginaceae) is one of the important medicinal herbs in traditional medicine. It has known for its variety effects such as demulcent, anti-inflammatory and analgesic, especially for common cold, anxiolytic and sedative, this plant contains small quantities of pyrrolizidine alkaloids that are toxic and chronic consumption may have adverse effects on the bodychr('39')s organs. in this study, 60 mice were chosen and divided into four groups. Group (1) as control group (without injection), group (2) received 12.5mg/kg, group (3) received 25mg/kg, group (4) received 50mg/kg body weight plant. Boraginaceae was injected into mice for a month. Then, the mice were decapitated and brains were collected to evaluate oxidative stress. The level of lipid oxidation was significant in groups. Brain tissue is rich in polyunsaturated fatty acid. Therefore, the level of lipid oxidation is usually more than other tissue. Changes in Ion reducing antioxidant capacity assay (CUPRAC) were not significant. The level of glutathione (GSH) increase in high dose. Echium Amoenum may don’t trigger toxicity in brain in low and intermediate doses.

Keywords: Echium Amoenum, Oxidative Stress, Brain
Full-Text [PDF 247 kb]   (271 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mohajer A, Araghi A, Sadighara P. P54: The Oxidative Stress Assessment of Echium Amoenum on Mice Brain . Shefaye Khatam. 2018; 6 (S1) :85-85
URL: http://shefayekhatam.ir/article-1-1661-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.04 seconds with 32 queries by YEKTAWEB 4212