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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 188-188 Back to browse issues page
P157: Periostin Recruits Tumor Associated Macrophages in Glioblastoma Multiform
Mahdieh Akbari *, Zahra Sagheb, Maral Haddadian
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (1198 Views)
Glioblastoma multiform (GBM) is the most common and lethal type of primary brain tumors with high rates of morbidity and mortality. Treatment options are limited and ineffective in most of the cases. Epidemiological studies have shown a link between inflammation and glioma genesis.  In addition, at the molecular level, pro-inflammatory cytokines released from activated microglia can increase proliferation of Glioma stem cells (GSCs) and migration of these cells to the inflamed area. GSCs increase tumor progression and decrease survival with several different mechanisms. One of the genes expressed in GSCs is POSTN. The product of this gene is a matricellular protein named periostin which has a critical role in carcinoma metastasis. This protein is up regulated in glioblastoma. A common feature of GBMs is abundant macrophage infiltration. Tumor-associated macrophages (TAM) have been shown to promote cancer cell proliferation, neo-vascularization and interfere with the anti-tumor functions of other immune cells. TAM density correlates with POSTN levels in human GBMs. POSTN causes an increase in cancer cell proliferation, invasion, TAM recruitment, and angiogenesis. As a result, it can be said that POSTN gene expression promotes GBM progression and it is possible to improve GBM by targeting POSTN gene.
Keywords: Glioblastoma Multiform, Inflammation, Glioma Stem Cells, POSTN, Tumor Associated Macrophages
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Akbari M, Sagheb Z, Haddadian M. P157: Periostin Recruits Tumor Associated Macrophages in Glioblastoma Multiform. Shefaye Khatam. 2018; 6 (S1) :188-188
URL: http://shefayekhatam.ir/article-1-1664-en.html

Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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