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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 197-197 Back to browse issues page
P166: The Role of Interlukin-6 of Immune Cells in Neuronal Dysfunctions in the Autism Disease
Sedighe Abdollahzadeh, Milad Ashrafizadeh *, Vahab Asemani
Department of Basic Science, Veterinary Medicine Faculty, Tabriz University, Tabriz, Iran , dvm.milad73@yahoo.com
Abstract:   (990 Views)
About thirty years ago, the interlukin-6 (IL-6) which is the proinflammatory cytokine, was detected as the differentiation factor of B cell. IL-6 is able to induce maturation in B cells and as a result, B cells achieve the ability to produce antibodies. In addition to immune responses, the role of IL-6 has been known in neurogenesis (neurons and glial cells). The studies have showed that the abnormal immune responses are associated to the autism. In the autism disease, the levels of cytokines increase in blood, brain and cerebrospinal fluid (CSF). Conclusion: Increased levels of IL-6 in the brain of mouse are related to the autism properties such as abnormal cognitive abilities, loss of learning, anxiety, abnormal habits and reduction of social behaviors. Furthermore, Increased levels of IL-6 are associated to preventing of the transmission of inhibiting/inducing synaptic secretions. Also, IL-6 results in abnormal changing in the shape, length and distribution pattern of dendritic cells and can be neurotoxic. Findings show that the increase of IL-6 in the brain can relatively mediate the autism-like behaviors which are created by unbalancing the neuron circuits and dysfunctions of synaptic formations. High expression of IL-6 in several major brain diseases and animal models shows that it can play an important role in neuropathology and that is why IL-6 is the target for strategic treatment.
Keywords: Autism, Interlukin, Nuerogenesis
Full-Text [PDF 247 kb]   (309 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Abdollahzadeh S, Ashrafizadeh M, Asemani V. P166: The Role of Interlukin-6 of Immune Cells in Neuronal Dysfunctions in the Autism Disease. Shefaye Khatam. 2018; 6 (S1) :197-197
URL: http://shefayekhatam.ir/article-1-1685-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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