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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 100-100 Back to browse issues page
P69: Effect of curcuma longa (Curcumin) in Neuropathic Pain Behavioral Response to CCI Model in Rat
Parnia Tarahomi *, Hossein Ali Safakhah, Farzaneh Mohammadzadeh, Ali Seyedinia Seyed, Ali Rashidy-Pour, Abbas Ali Vafaei
a. Neuropathic Pain Lab, Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran b. Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran , parnia.tarahomi@gmail.com
Abstract:   (1188 Views)

Treatment of neuropathic pain is still a major challenge because of its noresponsiveness to most available pharmacotherapy. Curcumin has been reported to play an active role in the treatment of various neurological disorders, such as neuropathic pain. In this study, the role of curcumin has been evaluated in pain behavioral responses of chronic Constriction injury (CCI) in rat. In this experimental study male Wistar rats (200–250 g) were used. Animals have been categorized as random based on groups of CCI, CCI with vehicle injection and CCI with 30 and 60 mg/kg Curcumin injection. For induction of CCI, Bennett & Xie (1988) method has been used applying CCI by 4 loose ligatures. Fourteen days after creation of neural injury, IP Injection of Vehicle and Curcumin have been started and continued to 26th day as daily. Animal behavioral responses have been measured using mechanical allodynia (Von Frey) and thermal hyperalgesia in 14 to 40th days After CCI. Data analyzed by one-way ANOVA and tukey test. Results indicated that CCI increases pain behavioral responses as significantly (P<0.05). Curcumin injection (30mg/Kg) leads to decrease of mechanical allodynia from 20th day and thermal hyperalgesia from 23th day. These effects have been continued to 40th day. Curcumin injection (60 mg/kg) leads to decrease of mechanical allodynia and thermal hyperalgesia only in 26th day. Based on findings, probably, curcumin can be effective on resulted neuropathy pains of CCI.

Keywords: Cci, Curcumin, Thermal Hyperalgesia, Mechanical Allodynia, Rat
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Tarahomi P, Safakhah H A, Mohammadzadeh F, Seyedinia A, Rashidy-Pour A, Vafaei A A. P69: Effect of curcuma longa (Curcumin) in Neuropathic Pain Behavioral Response to CCI Model in Rat. Shefaye Khatam. 2018; 6 (S1) :100-100
URL: http://shefayekhatam.ir/article-1-1687-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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