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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 202-202 Back to browse issues page
P171: Microglia Cell, Major Player in the Central Nervous System Inflammation
Masoud Azarakhsh, Farshid Hamidi *, Hadi Mohebalian
Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran , masoud.a.1369@gmail.com
Abstract:   (952 Views)
Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including alzheimerchr('39')s disease (AD), parkinsonchr('39')s disease (PD), and multiple sclerosis (MS). In the central nervous system, microglia, the resident innate immune cells play major role in the inflammatory process. Although they form the first line of defense for the neural parenchyma, uncontrolled activation of microglia may directly toxic to neurons by releasing various substances such as inflammatory cytokines (HMGB1, IL-1β, TNF-α, IL-6), NO, PGE and superoxide. Our recent study demonstrated that activated microglia, example BV2 cell, phagocytose not only damaged cell debris but also neighboring intact cells. These cells originated from yolk sac and fetal live in embryonic stage and after birth from bone marrow. Microglia bears some kinds of pattern recognition receptors (PRR) including TLR4 that can recognize pathogen associated molecular pattern(PAMP) and damage associated molecular pattern (DAMP). One of the most important items for PAMP is LPS which included in cell wall of bacteria especially gram negative bacteria. Moreover, LPS can be used by researchers in order to induction of inflammatory situation. It further supports their active participation in self-perpetuating neuronal damaging cycles. Besides, these interesting cells bear mannose and scavenger receptor for phagocytosis.
Keywords: Microglia Cell, Inflammation, LPS, CNS, Parkinson Disease
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Azarakhsh M, Hamidi F, Mohebalian H. P171: Microglia Cell, Major Player in the Central Nervous System Inflammation. Shefaye Khatam. 2018; 6 (S1) :202-202
URL: http://shefayekhatam.ir/article-1-1696-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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