[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 6 - The Spring Supplement of Shefaye Khatam 1 - ::
Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 203-203 Back to browse issues page
P172: Study the Effect of Carbamazepine During the Epileptogenesis by Dorsal Hippocampal Kindling on Balance and Locomotor Activity in Adult Male Rats
Reza Moghaddasi *, Ahmad Ali Moazedi, Zohreh Ghotbeddin, Mohammad Reza Akhoond
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran , ghr.moghaddasi@gmail.com
Abstract:   (976 Views)
Epilepsy is a chronic cerebral disorder associated with recurrently occurring seizures resulting from over activity of brain neurons. Since more than one percent of the worldchr('39')s population is suffering from epilepsy, this disease is recognized as one of the most important neurological disorders in modern medicine. Studies indicate that impairment in balance and motor activity are known as one of the side effects of epilepsy. Therefore, the use of an antiepileptic drug such as carbamazepine can help to improve these disorders. So, in this research, the effect of carbamazepine during epileptogenesis in dorsal hippocampal kindling on balance and motor activity in adult male rats was investigated. In this study, 60 adult male rats were randomly divided into 6 groups: surgical control, methylcellulose (MC), Kindled, carbamazepine (CBZ), kindled-carbamazepine (KCBZ) and the methylcellulose-Kindled (MCK). Animals in the Kindled group stimulate were rapidly kindled by daily stimulation of dorsal hippocampus (12 stimulation per day, 1 ms pulse duration at 50Hz for 3 seconds) in the dorsal hippocampus region(CA1). While animals in the control groups did not receive any stimulation. Animals in the CBZ group received 8 mg of carbamazepine intraperitoneally on the first day after the recovery. The CBZK-group, in addition to receiving 8 mg of carbamazepine on the first day after recovery, received kindling stimulations for 6 days, as the same method with Kindled group. The MCK-group was similar to the CBZK-group with this difference that they received MC instead of CBZ. At the end of kindling stimulation, open field and rotarod tests were respectively used to examine the effect of CBZ on motor activity and balance. The open field test results showed a significant decrease in the motions and rearing frequency in the CBZK-group compared to the MCK-group (p <0.01). Frequency of rearing and motions in the Kindled group also showed a significant increase compared to the control group (p <0.01). Grooming in the CBZK-group compared to the MCK-group show significant decrease (p <0.05) and in the Kindled group showed a significant increase compared to the control group (p <0.05). In the Rotarod test, the balance in the Kindled group was significantly lower than the control group (p <0.05) and in the CBZK-group compared to the MCK-group show significant increase (p <0.01). It seems that Carbamazepine injection during the epileptogenesis by dorsal hippocampal kindling in male rats reduces motor activity but improves balance.
Keywords: Hippocampal Kindling, Carbamazepine, Balance, Motor Activity, Rotarod Test, Open Field Test, Rat
Full-Text [PDF 255 kb]   (335 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moghaddasi R, Moazedi A A, Ghotbeddin Z, Akhoond M R. P172: Study the Effect of Carbamazepine During the Epileptogenesis by Dorsal Hippocampal Kindling on Balance and Locomotor Activity in Adult Male Rats. Shefaye Khatam. 2018; 6 (S1) :203-203
URL: http://shefayekhatam.ir/article-1-1698-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.04 seconds with 32 queries by YEKTAWEB 4212