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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 121-121 Back to browse issues page
P90: The Relationship between the TNFα of the Microglia Cells and the Alzheimer Disease
Vahab Asemani *, Milad Ashrafizadeh, Sedighe Abdollahzadeh
Department of Basic Science, Veterinary Medicine Faculty, Tabriz University, Tabriz, Iran , dvm.milad73@yahoo.com
Abstract:   (908 Views)

TNFα is one of the most important inflammatory cytokines which induces caspase and apoptotic process. There are two forms of TNFα: soluble TNFα (solTNFα) and transmembrane TNFα (tmTNFα). These inflammatory cytokines have two receptors namely TNRF1 and TNRF2. The attachments of the cytokines to those receptors induce the TRAF and activate the NK-Kb. TNFR1 is found in most of the cells and solTNFα and tmTNFα have the ability to attach to the TNFR1, but the TNFR2 is just found in the microglia and endothelial cells and reacts with the tmTNFα. Microglia is one of the smallest cells in the CNS which has the ability of phagocytosis and is one of the first cells which responds to the inflammations and exogenous factors. In general, there is a balance between the levels of the solTNFα and tmTNFα, but in the CNS disorders, in according to the damages in the neurons and disturbances in the cell conditions, that balance is interrupted and one of the cytokines is secreted more than normal level. One of the most important chronic neurodegenerative damages that is stimulated by TNFα, is Alzheimer disease. In the Alzheimer disease, activated microglia cells increase the levels of the TNFα which inclines the extracellular b-Amyloid, tau protein, intracellular neurofibrillary tangles and microgliosis that these changes lead to synaptic dysfunctions and neuronal destruction.

Keywords: TNF, CNS, Microglia, Alzheimer
Full-Text [PDF 248 kb]   (307 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Asemani V, Ashrafizadeh M, Abdollahzadeh S. P90: The Relationship between the TNFα of the Microglia Cells and the Alzheimer Disease. Shefaye Khatam. 2018; 6 (S1) :121-121
URL: http://shefayekhatam.ir/article-1-1725-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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