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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 135-135 Back to browse issues page
P104: Obesity-Induced Neuroinflammation: Focus on Hypothalamic Inflammation
Maryam Moghadam *, Zahra Sheidae Mehne
Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran , Maryammghdm20@gmail.com
Abstract:   (1116 Views)
Obesity is a Health issue around the world. Obesity is not limited to body weight, generally associated with low grade inflammation and with a cluster of disorders generally referred to as "metabolic syndrome". Regarding obesity and relapse, long-term concentration was set on the hypothalamus. Most recently,obesity- Originated neuroinflammation has been shown to affect other brain structures such as the hippocampus,cortex, brainstem, oramygdala. Additionally, obesity is accompanied by an increase in central disturbances such as depression and cognitive impairment. The hypothalamus is a key brain region in the regulation of energy balance. The hypothalamus is a key brain region in regulating energy balance. Especially controls food intake and both energy storage and expenditure through integration of humoral, neural and nutrient-related signals. The hypothalamus cells and glial cells act jointly to orchestrate. We discuss the effects and mechanisms of obesity- originated neuroinflammation, with a specific emphasis on extra-hypothalamic structures, as well as the consequences of neuroinflammation for some cerebral functions. Therefore, the existence of a causal link between hypothalamic inflammation and deregulations of feeding behavior, such as involuntary weight-loss or obesity, has been recommended. Among the inflammatory mediators that could induce deregulations of hypothalamic control of the energy balance, chemokines represent interesting candidates. Chemokines, primarily known for their chemical absorption role of immune cells to the inflamed site, have also been recommended capable of neuromodulation.
Keywords: Obesity, Neuroinflammation, Hypothalamus
Full-Text [PDF 238 kb]   (322 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Moghadam M, Sheidae Mehne Z. P104: Obesity-Induced Neuroinflammation: Focus on Hypothalamic Inflammation. Shefaye Khatam. 2018; 6 (S1) :135-135
URL: http://shefayekhatam.ir/article-1-1735-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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