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Neurotransmitters Play as a Key Role in Adult Neurogenesis
Vahid Hajali , Hamid Reza Moradi , Sajad Sahab Negah *
a. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , sahabnegahs@mums.ac.i
Abstract:   (100 Views)

Introduction: New neurons are constantly created in specific areas of the adult brain and functionally integrated into neuronal networks. Neural stem cells exist in specific microenvironments in the brain called the stem cell niches. It has been shown that neurotransmitters provide vital components of the niche signals and modulate several aspects of neurogenesis. It has been demonstrated that changes in neurotransmitter signaling may influence adult neurogenesis. Further works are required to clarify how neurotransmitter signaling pathways control neurogenesis. Conclusion: In this review, we discuss how neurotransmitter signaling regulates the development of new functional neurons. We also review the potential roles of neurotransmitters for cell therapy.

Keywords: Neurogenesis, Neurotransmitter Agents, Cell- and Tissue-Based Therapy
Full-Text [PDF 1031 kb]   (5 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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