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Shefaye Khatam 2018, 6 - The Summer Supplement of Shefaye Khatam 2 -: 38-38 Back to browse issues page
P11: The Role of Aquaporin-4Receotors in Mesial Temporal Epilepsy
Zeinab Najmi, Mostafa Modarres Mousavi Sayed *
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran , modarres.mousavi@gmail.com
Abstract:   (1088 Views)
Introduction: Aquaporin-4 (AQP4) express in glial cells and plays a crucial role in brain water and ion homeostasis during rapid neural activity. Only AQP-4 has been found in astrocyte, which is widely expressed throughout the brain, especially in the cerebrospinal fluid and cerebrospinal fluid (CSF) interface, which may have contributed to edema and CSF absorption. Mesial temporal lobe epilepsy (MTLE) is a chronic seizure disorder that is often refractory to epilepsy treatment. The main cause of MTLE is not fully understood, but the ability to hyperexcitability in neuronal networks is an essential feature. Loss of AQP4 from perivascular endfeet of sclerotic hippocampus contributes to increased seizure propensity in human MTLE. Conclusion: In conclusion, mislocalization of AQP4 in different regions of hippocampus may contribute to the epileptogenicity of the MTLE patients.
Keywords: Temporal Epilepsy, Glial Cells, AQP4, Epileptogenicity
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Najmi Z, Modarres Mousavi M. P11: The Role of Aquaporin-4Receotors in Mesial Temporal Epilepsy. Shefaye Khatam. 2018; 6 (S2) :38-38
URL: http://shefayekhatam.ir/article-1-1816-en.html

Volume 6 - The Summer Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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