[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Registration::
Site Facilities::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 

..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Volume 6 - The Summer Supplement of Shefaye Khatam 2 - ::
Shefaye Khatam 2018, 6 - The Summer Supplement of Shefaye Khatam 2 -: 39-39 Back to browse issues page
P12: Mitochondrial Dysfunction and Oxidative Stress in Epilepsy
Shiri Elham , Akram Shiri , Maryam Borhani-Haghighi * , Fatemeh Alipour
a. Department of Anatomy, School of Medicine, Tehran University of Medical Science, Iran. b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , Borhanihm@gmail.com
Abstract:   (2848 Views)
Introduction: Mitochondria have essential functions such as the generation of ATP, metabolite/neurotransmitter synthesis, fatty acid oxidation, calcium homeostasis, control of cell death and they are the primary source of reactive oxygen species (ROS) production. Mitochondrial dysfunction and oxidative stress play a pivotal role in several neurological disorders and recently the changes in mitochondria function have been shown in acquired epilepsies. An acute increase in mitochondrial oxidative stress and following damage to cellular macromolecules have been demonstrated in repeated seizures i.e. status epilepticus (SE). On the other hand, mitochondrial dysfunction and oxidative stress reported in other disorders such as hypoxic-ischemic insults, traumatic brain injury, viral infection, and hyperthermia which can lead to chronic acquired epilepsies. In addition, epilepsy has been seen in disorders led by mutations in mtDNA and nuclear genes. Mitochondrial dysfunction during chronic epilepsy is characterized by a decrease in ETC complex I and IV activity, increase in complex II activity, and a decline in mitochondrial membrane potential in the CA1 and CA3 regions of hippocampus one month after pilocarpine-induced SE. It can be proposed that inhibition of complex I in mitochondria can lead to a rise in ROS production and/or RNS (Reactive nitrogen species) which may cause not only neuronal injury demonstrated in a model of seizures but also epileptogenesis. In recent years, a paramount of fundamental research has been directed toward developing pharmacologic approaches to restore mitochondria function. Conclusion: Evaluation of mitochondrial damage in epilepsy and the specific targeting of mitochondrial oxidative stress, malfunction, and bioenergetics may be novel strategies for decreasing epileptogenesis and seizure initiation.
Keywords: Epilepsy, Mitochondrial Dysfunction, Oxidative Stress
Full-Text [PDF 219 kb]   (901 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Elham S, Shiri A, Borhani-Haghighi M, Alipour F. P12: Mitochondrial Dysfunction and Oxidative Stress in Epilepsy. Shefaye Khatam 2018; 6 (S2) :39-39
URL: http://shefayekhatam.ir/article-1-1818-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6 - The Summer Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4639