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:: Volume 6 - The Summer Supplement of Shefaye Khatam 2 - ::
Shefaye Khatam 2018, 6 - The Summer Supplement of Shefaye Khatam 2 -: 39-39 Back to browse issues page
P12: Mitochondrial Dysfunction and Oxidative Stress in Epilepsy
Shiri Elham , Akram Shiri , Maryam Borhani-Haghighi * , Fatemeh Alipour
a. Department of Anatomy, School of Medicine, Tehran University of Medical Science, Iran. b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , Borhanihm@gmail.com
Abstract:   (2848 Views)
Introduction: Mitochondria have essential functions such as the generation of ATP, metabolite/neurotransmitter synthesis, fatty acid oxidation, calcium homeostasis, control of cell death and they are the primary source of reactive oxygen species (ROS) production. Mitochondrial dysfunction and oxidative stress play a pivotal role in several neurological disorders and recently the changes in mitochondria function have been shown in acquired epilepsies. An acute increase in mitochondrial oxidative stress and following damage to cellular macromolecules have been demonstrated in repeated seizures i.e. status epilepticus (SE). On the other hand, mitochondrial dysfunction and oxidative stress reported in other disorders such as hypoxic-ischemic insults, traumatic brain injury, viral infection, and hyperthermia which can lead to chronic acquired epilepsies. In addition, epilepsy has been seen in disorders led by mutations in mtDNA and nuclear genes. Mitochondrial dysfunction during chronic epilepsy is characterized by a decrease in ETC complex I and IV activity, increase in complex II activity, and a decline in mitochondrial membrane potential in the CA1 and CA3 regions of hippocampus one month after pilocarpine-induced SE. It can be proposed that inhibition of complex I in mitochondria can lead to a rise in ROS production and/or RNS (Reactive nitrogen species) which may cause not only neuronal injury demonstrated in a model of seizures but also epileptogenesis. In recent years, a paramount of fundamental research has been directed toward developing pharmacologic approaches to restore mitochondria function. Conclusion: Evaluation of mitochondrial damage in epilepsy and the specific targeting of mitochondrial oxidative stress, malfunction, and bioenergetics may be novel strategies for decreasing epileptogenesis and seizure initiation.
Keywords: Epilepsy, Mitochondrial Dysfunction, Oxidative Stress
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Elham S, Shiri A, Borhani-Haghighi M, Alipour F. P12: Mitochondrial Dysfunction and Oxidative Stress in Epilepsy. Shefaye Khatam 2018; 6 (S2) :39-39
URL: http://shefayekhatam.ir/article-1-1818-en.html

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6 - The Summer Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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