[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 6, Issue 4 (Autumn - 2018) ::
Shefaye Khatam 2018, 6(4): 1-4 Back to browse issues page
Axon Guidance Proteins: A Novel Target Point for Temporal Lobe Epilepsy
Sajad Sahab Negah * , Ali Jahanbazi Jahan-Abad , Mostafa Modarres Mousavi Sayed
a. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , sahabnegahs@mums.ac.ir
Abstract:   (300 Views)
Introduction: Epilepsy is primarily a neuronal network disorder characterized by recurrent and unpredictable seizures. Epilepsy is not only characterized by marked changes in ion channels but also by the abnormal synaptic protein expression. It has been reported that the expression of axon guidance proteins was changed in experimental models of epilepsy. In this letter to the editor, we review and discuss the changes of axon guidance proteins in epilepsy. Conclusion: Collectively, further insight into dysregulation of axon guidance proteins may help to develop novel therapeutic strategies for epilepsy.
Keywords: Axon Guidance, Epilepsy, Hippocampus
Full-Text [PDF 459 kb]   (56 Downloads)    
Type of Study: Letter to Editor --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
References
1. Morelli E, Ghiglieri V, Pendolino V, Bagetta V, Pignataro A, Fejtova A, et al. Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice. Exp Neurol. 2014;261:320-7. [DOI:10.1016/j.expneurol.2014.05.010]
2. Fukata Y, Fukata M. Epilepsy and synaptic proteins. Current Opinion in Neurobiology. 2017;45:1-8. [DOI:10.1016/j.conb.2017.02.001]
3. Lin L, Lesnick TG, Maraganore DM, Isacson O. Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics. Trends in Neurosciences. 2009;32(3):142-9. [DOI:10.1016/j.tins.2008.11.006]
4. Kolodkin AL, Tessier-Lavigne M. Mechanisms and molecules of neuronal wiring: a primer. Cold Spring Harbor Perspectives in Biology. 2011;3(6): 1-15. [DOI:10.1101/cshperspect.a001727]
5. Izzi L, Charron F. Midline axon guidance and human genetic disorders. Clinical Genetics. 2011;80(3):226-34. [DOI:10.1111/j.1399-0004.2011.01735.x]
6. Nugent AA, Kolpak AL, Engle EC. Human disorders of axon guidance. Current Opinion in Neurobiology. 2012;22(5):837-43. [DOI:10.1016/j.conb.2012.02.006]
7. Van Battum EY, Brignani S, Pasterkamp RJ. Axon guidance proteins in neurological disorders. The Lancet Neurology. 2015;14(5):532-46. [DOI:10.1016/S1474-4422(14)70257-1]
8. Xia Y, Luo C, Dai S, Yao D. Increased EphA/ephrinA expression in hippocampus of pilocarpine treated mouse. Epilepsy Res. 2013;105(1-2):20-9. [DOI:10.1016/j.eplepsyres.2013.01.001]
9. Fang M, Liu GW, Pan YM, Shen L, Li CS, Xi ZQ, et al. Abnormal expression and spatiotemporal change of Slit2 in neurons and astrocytes in temporal lobe epileptic foci: a study of epileptic patients and experimental animals. Brain Res. 2010;1324:14-23. [DOI:10.1016/j.brainres.2010.02.007]
10. Koyama R, Ikegaya Y. Mossy fiber sprouting as a potential therapeutic target for epilepsy. Curr Neurovasc Res. 2004;1(1):3-10. [DOI:10.2174/1567202043480242]
11. Babb TL, Pretorius JK, Mello LE, Mathern GW, Levesque MF. Synaptic reorganizations in epileptic human and rat kainate hippocampus may contribute to feedback and feedforward excitation. Epilepsy Res Suppl. 1992;9:193-202.
12. Holtmaat AJ, Gorter JA, De Wit J, Tolner EA, Spijker S, Giger RJ, et al. Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. a novel molecular event potentially contributing to mossy fiber sprouting. Exp Neurol. 2003;182(1):142-50. [DOI:10.1016/S0014-4886(03)00035-9]
13. Barnes G, Puranam RS, Luo Y, McNamara JO. Temporal specific patterns of semaphorin gene expression in rat brain after kainic acid-induced status epilepticus. Hippocampus. 2003;13(1):1-20. [DOI:10.1002/hipo.10041]
14. Saffarzadeh F, Eslamizade MJ, Ghadiri T, Modarres Mousavi SM, Hadjighassem M, Gorji A. Effects of TRPV1 on the hippocampal synaptic plasticity in the epileptic rat brain. Synapse. 2015;69(7):375-83. [DOI:10.1002/syn.21825]



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sahab Negah S, Jahanbazi Jahan-Abad A, Modarres Mousavi M. Axon Guidance Proteins: A Novel Target Point for Temporal Lobe Epilepsy. Shefaye Khatam. 2018; 6 (4) :1-4
URL: http://shefayekhatam.ir/article-1-1825-en.html


Volume 6, Issue 4 (Autumn - 2018) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3764