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دوره 7 شماره 1 صفحات 91-105 برگشت به فهرست نسخه ها
نقش آپتامرها در درمان گلیوبلاستوم مولتی‌فرم
صادق شیریان* ، رضا ختوان هفشجانی، احسان عالی، سید مصطفی مدرس موسوی، سارا عبدالهی، نسرین لطفی بخشایش
گروه پاتولوژی، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران ، Shiran85@gmail.com, rezakhetvan@gmail.com
چکیده:   (465 مشاهده)
مقدمه: گلیوبلاستوم مولتی‌فرم یا گلیوما درجه ۴ متداول‌ترین و تهاجمی‌ترین تومور اولیه مغز انسان است. گلیوبلاستوم مولتی‌فرم اولیه که به طور خود به خودی از سلول‌های گلیا ایجاد می‌شود و اکثریت قریب به اتفاق گلیوبلاستوم مولتی‌فرم را تشکیل می‌دهند معمولاً مربوط به تقویت و جهش گیرنده فاکتور رشد اپیدرمی، حذف فسفاتاز و (tensin homolog (PTEN روی کروموزوم 10، حذف P16 و جهش در پروموتور TERT می‌شود. علی‌رغم پیشرفت‌های درمانی در چند دهه اخیر میانگین زمان زنده ماندن بیماران مبتلا به گلیوبلاستوم مولتی‌فرم 12/1 تا 14/6 ماه بعد از تشخیص است و تنها 5-3 درصد از بیماران بیش از ۳ سال زنده می‌مانند. تأثیر درمان‌های معمول شامل: جراحی، رادیوتراپی، شیمی درمانی و ترکیب رادیوتراپی و شیمی درمانی اثر بسیار کمی دارند. هرچند جراحی و استفاده از Temozolomideدر طول و بعد از دوره رادیوتراپی زمان زنده مانده بیماران را افزایش می‌دهد، اما آن‌ها دارای عوارض جانبی متعددی هستند. بنابراین معرفی یک دارو جدید که قادر به مهار رشد سلول گلیوبلاستوم مولتی‌فرم، تکثیر، متاستاز و تهاجم است، نیاز است. از آنجایی که سلول‌های سرطانی دارای مولکول‌های سطحی هستند که بیش از حد بیان شده و تغییر یافته هستند، ساختارهای مولکولی به نام آپتامر با استفاده از فرایند SELEXر(Systematic Evolution of Ligands by Exponential enrichment) برای مورد هدف قرار دادن مولکول‌های سطحی طراحی شده‌اند. تا امروز آپتامرهای زیادی با مزایا و معایب برای درمان بیماری‌های مختلف از جمله سرطان که در این مطالعه مورد بحث قرار گرفته‌است، به کار برده شده‌اند. نتیجه‌گیری: اخیراً با استفاده از فرایند SELEX که نشان‌دهنده پتانسیل بالای آپتامرها در مدیریت گلیوبلاستوم مولتی‌فرم است، چندین آپتامر با قابلبیت شناسایی بالای گلیوبلاستوم مولتی‌فرم طراحی شده است.
واژه‌های کلیدی: گلیوبلاستوما، آپتامرهای نوکلئوتیدی، الیگودندروگلیوما
متن کامل [PDF 778 kb]   (74 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: نوروبيولوژي مولكولي
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Shirian S, Khetvan-Hafshejani R, Ali E, Modarres Mousavi M, Abdollahi S, Lotfi Bakhshaiesh N. The Role of Aptamers in the Treatment of Glioblastoma Multiform. Shefaye Khatam. 2019; 7 (1) :91-105
URL: http://shefayekhatam.ir/article-1-1866-fa.html

شیریان صادق، ختوان هفشجانی رضا، عالی احسان، مدرس موسوی مصطفی، عبدالهی سارا، لطفی بخشایش نسرین. نقش آپتامرها در درمان گلیوبلاستوم مولتی‌فرم. مجله علوم اعصاب شفای خاتم. 1397; 7 (1) :91-105

URL: http://shefayekhatam.ir/article-1-1866-fa.html



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مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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